This work was supported by the AO Foundation and AO CMF. The sponge is then designed to resorb, or disappear, over time. The most productive year in terms of publications was 1997 (), followed by 2000 and 2005, with 6 publications each. Background. Concerning the evolution of scientific production, few dental specialties including Periodontology  or Implantology  have undergone a hike in the quantity of research published in recent years. Based on normality and distribution of the data, the mean (standard deviation) or median (interquartile range) was calculated. Bone morphogenic protein is an isolated protein that induces specific cells in our body to form new cartilage and bone.During surgery, the BMP is soaked onto and binds with a collagen sponge. The reason is quite evident from the fact that this is the same institute where BMPs were discovered in the 1960s by Marshall R. Urist. The Journal of Dental Research had the highest citation count (), followed by the Journal of Periodontology () and Clinical Oral Implants Research (). /Subtype /Type0 The true influence of a research article can be determined properly at least 20 years after its publication [44, 65, 76]. Approximately 1 in every 500-700 children is born with a cleft lip, cleft palate or both, worldwide. Conclusion. Request a consult or call 717-763-1970 for more information. T1 - The application of bone morphogenetic proteins to dental tissue engineering. Die BMPs werden auch als parakrine Signalmoleküle bezeichnet. The third-ranked article was the animal study written by Urist and Strates in 1971, with 15 new citations . Many of the articles () had between one and six authors, but publications with more than five authors were the most common (). Using your body’s existing healing channels is the best way to promote healing and growth, and the FDA has approved BMP is useful for a variety of oral surgery procedures. Most of the publications were animal studies () and focused on BMP-2 (). The osteoinductive capacity of BMPs has led to their application as therapeutic agents for the generation of new bone in order to treat skeletal injuries . An electronic search was conducted using the Web of Science (WoS) “All Databases” without any restriction of language, study design, or publication year. (2)CiteScore (CS): this is a newly introduced indicator adopted to assess the impact of journals so that more rigorous results can be obtained. % Creation date: 10/24/2020 10:13:13 AM The remaining bibliometrics are less well-known as predictors of citations; for instance, the number of publications at least scales with a journal size; however, it does not consider quality; this left the ES as a victor in an unbalanced contest . Bone Morphogenetic Protein (BMP2-Infuse) Bone morphogenic protein is a revolutionary growth factor that induces stem cells in our body to form new bone. Expression Patterns of Bone Morphogenetic Proteins (Bmps) in the Developing Mouse Tooth Suggest Rolesin Morphogenesis and Cell Differentiation THOMAS ÅBERG,1,2 JOHN WOZNEY,3 AND IRMA THESLEFF1,2* 1Institute of Biotechnology, University of Helsinki, Helsinki, Finland 2Institute of Dentistry, University of Helsinki, Helsinki, Finland 3Genetics Institute, Cambridge, Massachusetts While only a small amount of BMP is produced naturally, lab-derived proteins can be produced at significantly higher quantities and be used to aid in the body’s own healing process after surgery. Balaji is a pioneer at using the bone-creating protein rhBMP-2 in dental implant surgery and has performed numerous such treatments with great success. The second-ranked article was also the RCT written by Jung et al., in 2003, with 16 citations . B. da Silva, F. W. de Paula e Silva, M. R. Leonardo, and S. Assed, “Pulpal and periapical response of dogs' teeth after pulpotomy and use of recombinant human bone morphogenetic protein-7 as a capping agent,”, M. Narukawa, N. Suzuki, T. Takayama, T. Shoji, K. Otsuka, and K. Ito, “Enamel matrix derivative stimulates chondrogenic differentiation of ATDC5 cells,”, Z.-M. Lin, W. Qin, N. H. Zhang, L. Xiao, and J. Q. Ling, “Adenovirus-mediated recombinant human bone morphogenetic protein-7 expression promotes differentiation of human dental pulp cells,”, S. Cabrera, D. Barden, M. Wolf, and D. Lobner, “Effects of growth factors on dental pulp cell sensitivity to amalgam toxicity,”, A. Bone Morphogenetic Protein. >> endobj The Kruskal-Wallis test was done to check median differences between the independent groups. Bone fractures represent a significant medical morbidity among aged population with osteoporosis. Bone morphogenetic proteins are major regulators of bone formation, and prostate tumor cells frequently express several of the BMPs (Bentley et al., 1992; Koeneman et al., 1999). Other variables are worth mentioning: each dental specialty shows different impact factor thresholds; for instance, a journal in the general dentistry (Journal of Dental Research) field might have an impact factor up to 40 times as high as the corresponding figure in the oral surgery category. A statistically nonsignificant trend () was observed between a journal age and the number of “classic” articles published in that journal. BMP-2, BMP-4, and BMP-7 have been reported to stimulate in vivo, in vitro, and de novo bone formation in several animal models [13, 14, 16, 18]. A statistically significant association was observed between citation count, citation density, and age of publication. Dental implants anchor the permanent prosthetic teeth to the bone. (3)Eigenfactor Score (ES): this is regarded as an indicator of the global repercussions or impact of documents published online in JCR. Marshall R. Urist. The third ranked article was the RCT conducted by Triplett and coworkers, in 2009, with a citation density of 17.60 . Die knochenmorphogenetischen Proteine (englisch bone morphogenetic proteins, BMPs) sind eine Gruppe einander ähnlicher Signalproteine, die von Tierzellen ausgeschüttet werden, um benachbarte Zellen zu beeinflussen, so genannte Zytokine. According to the CCI 2019, the top-ranked article was the randomized controlled trial (RCT) published in 2005, securing 22 citations . Bone Morphogenetic Protein 2 - Creekstone Dental Bone Morphogenetic Protein 2 BMP-2, or Bone Morphogenetic Protein 2, is a protein that is already present in … Van Eck and L. Waltman, “Software survey: VOSviewer, a computer program for bibliometric mapping,”, J. P. Fiorellini, T. H. Howell, D. Cochran et al., “Randomized study evaluating recombinant human bone morphogenetic protein-2 for extraction socket augmentation,”, K. Iohara, M. Nakashima, M. Ito, M. Ishikawa, A. Nakasima, and A. Akamine, “Dentin regeneration by dental pulp stem cell therapy with recombinant human bone morphogenetic protein 2,”, R. E. Jung, R. Glauser, P. Schärer, C. H. F. Hämmerle, H. F. Sailer, and F. E. Weber, “Effect of rhBMP-2 on guided bone regeneration in humans,”, P. J. Boyne, L. C. Lilly, R. E. Marx et al., “De novo bone induction by recombinant human bone morphogenetic protein-2 (rhBMP-2) in maxillary sinus floor augmentation,”, R. G. Triplett, M. Nevins, R. E. Marx et al., “Pivotal, randomized, parallel evaluation of recombinant human bone morphogenetic protein-2/absorbable collagen sponge and autogenous bone graft for maxillary sinus floor augmentation,”, M. Cicciù, A. Scott, D. Cicciù, R. Tandon, and C. Maiorana, “Recombinant human bone morphogenetic protein-2 promote and stabilize hard and soft tissue healing for large mandibular new bone reconstruction defects,”, A. Fardi, K. Kodonas, T. Lillis, and A. Veis, “Top-cited articles in implant dentistry,”, P. Ahmad, P. M. H. Dummer, T. Y. Noorani, and J. % PDFsharp Version 1.32.2608.0 (verbose mode) Bone-thinning is a common cause and consequence following tooth loss. Mol Reprood Dev 1992;32:160-7. THE APPLICATION OF BONE MORPHOGENETIC PROTEINS TO DENTAL TISSUE ENGINEERING A review article by: Misako Nakashima & A Hari Reddi Source :- NATURE BIOTECHNOLOGY, VOLUME 21, NO. Though BMP-mediated fracture healing has been well-documented in preclinical models, there has been no clinical study that demonstrated unequivocally … The Visualization of Similarities viewer (VOSviewer) software  was used to create collaboration network maps regarding the cooccurrences of all keywords. Bibliometric analysis is helpful to determine the most influential studies in a specific field. Bone induction is a sequential multistep cascade. The top 50 most-cited studies were published between 1971  and 2014  (Figure 2(a)). Bone morphogenetic protein 6 stimulates mineralization in human dental follicle cells without dexamethasone Arch Oral Biol. This bibliometric analysis is aimed at identifying and analyzing the top 50 most-cited articles on the dental applications of BMPs. They have become a likely treatment option, given their action on regeneration and remodeling of bone lesions and increasing the bone response around … % File size: 1379896 bytes Bone morphogenetic proteins (BMPs) are suggested to have therapeutic potential to enhance fracture healing in such patients. However, the utilization of BMPs is not limited to osteogenic regeneration; there are other research areas including tooth conservation and periodontal regeneration procedures [24–29]. Several bibliometric studies have reported that authors hailing from institutions of Asia and Africa whether being the first or the corresponding authors made an almost negligible contribution which could be regarded as the “classic article” [76, 83, 88, 90, 91]. Within a few months, your dentist will measure the bone growth and reassess the treatment plan. The sponge is then designed to resorb, or disappear, over time. Supplementary Table 1 depicts the principal characteristics of the top 50 most-cited articles. This analysis was exempt from the institutional ethics committee review as it was a bibliometric review. Hence, the findings of the present study not only depict a historical perspective on scientific advancement on BMPs but also display principal trends in research as well as clinical practice. In dentistry, BMPs, particularly BMP-2, are being widely used in many procedures such as alveolar bone regeneration [8, 13–15, 17, 30], sinus lift augmentation [3, 5, 31], dental implants [16, 32], and periodontal [33–37] and dental regeneration [24–29]. Present Status of Bone Morphogenetic Proteins in Dentistry: Koudale, Somnath, Bhongade, Monohar, Deshpande, Aniruddha: Amazon.sg: Books Supplementary 2. Role of Bone Morphogenetic Proteins in Periodontics Dr.Jaishree Tukaram Kshirsagar, MDS, Dr.Aruna Kaveri Professor, Department of Periodontics, Tamilnadu Government Dental College & Hospital, Chennai, TamilNadu . The Mann-Kendall trend test was utilized to analyze any increase or decrease in the time-dependent trends. This trend of publication highlights the influence of the impact factor of a journal and the inclination of authors to cite and article that is published in a high impact factor journal within a given specialty. Bone morphogenetic proteins (BMPs) are a group of regulatory glycoproteins that are members of the transforming growth factor-beta superfamily. The impact factor and citations in peer-reviewed publications are a widely recognized measure of scientific impact . Abstract. The sponge is then designed to resorb, or disappear, over time. Bone Morphogenetic Protein Show all authors. Between 2000 and 2005, research activity took off seeing the greatest number of published studies ever (22/50 articles). Scientists, funding agencies, and research organizations necessitate metrics to determine the impact of research. At Brighton Specialty Dental Group, our dentists, Dr. Homa H. Zadeh and associates, and our team believe in embracing many forms of medical technology to improve not only patient treatment but oral and dental health as well. Its citation density is 17.40, with a CCI of 11. 3 0 obj % PdfSharp.Pdf.PdfDictionary >> Sasikumar KP, Elavarasu S, Gadagi JS. These are exciting times in the field of BMPs, and their potent osteoinductive properties place them on the threshold of clinical applications in dentistry. , 1986 ; Masuda, Fukabori, Nakano, Shimizu, & Yamanaka, 2004 ). Although there is considerable interest in the use of bone morphogenetic protein (BMP) to promote periodontal regeneration, little is known of its effects on the early stages of wound healing. Bibliometric analysis is helpful to determine the most influential studies in a specific field. IBM SPSS Statistics version 24.0 (IBM, Chicago, IL) was used to perform descriptive and bivariate analyses. Of the BMP family BMP 2, 7, and 6 have been associated with osteoblastic metastases ( Bentley et al. %���� Bone morphogenic protein is an isolated protein that induces specific cells in our body to form new cartilage and bone.During surgery, the BMP is soaked onto and binds with a collagen sponge. During surgery, the BMP is soaked onto and binds with a collagen sponge. Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β (TGF-β) superfamily. We are committed to sharing findings related to COVID-19 as quickly as possible. 1 0 obj % PdfSharp.Pdf.PdfDictionary Dr. S.M. Background: Bone defects and irregularities are major problems for dental implant and periodontal therapies. The bone morphogenetic protein solution component must not be used without the carrier/scaffold component or with a carrier/scaffold component different from the one described in the package insert. Though BMP-mediated fracture healing has been well-documented in preclinical models, there has been no clinical study that demonstrated unequivocally … A total of 182 keywords were identified (Figure 5). /ToUnicode 6 0 R Bone morphogenetic proteins (BMPs), originally identified as osteoinductive components in extracts derived from bone, are now known to play important roles in a wide array of processes during formation and maintenance of various organs including bone, cartilage, muscle, kidney, and … Chitosan/collagen scaffold containing bone morphogenetic protein‐7 DNA supports dental pulp stem cell differentiation in vitro and in vivo † Xuechao Yang Key Lab for Oral Biomedicine of Ministry of Education and Department of Endodontics, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei Province, People's Republic of China Bone morphogenetic proteins: The anomalous molecules. Abstract- Bone Morphogenetic Proteins which are part of extracellular matrix are capable of inducing de novo bone formation. This po- tential is expanded by the option to introduce exogenous BMPs synthesized through recombinant technology. More than 30 BMPs have been identified in different organisms to date, including mammals, sea urchin, C. elegans, Xenopus, and Drosophila [1, 2], and now, they are acknowledged in their role as pleiotropic growth factors found both in vertebrates and in invertebrates . First, for a particular research area, many factors may affect the citation count, including article age, journal of publication, author’s reputation, institution, and country of origin as well as the original language. The journals’ ranking based on their impact factor has become a principle consideration when authors decide where to submit their research. Huo, X. H. Pan, Q. Its citation density is 11.60, with a current citation index (CCI) of 15. Search for more papers by this author. During surgery, the BMP is placed with a special collagen sponge. Journals’ impact factors ranged from 0.785 (Journal of Craniofacial Surgery) to 5.125 (Journal of Dental Research). Many articles on bone morphogenetic proteins (BMPs) have been published. Sign up here as a reviewer to help fast-track new submissions. AU - Nakashima, Misako. % Pages: 12 The sponge is then designed to resorb, or disappear, over time. Bone Morphogenetic Protein. Furthermore, to an unparalleled research work, an increased tendency among authors to cite articles originating from the US has been observed [88, 89]. Bone morphogenetic protein is an isolated protein that induces specific cells in our body to form new cartilage and bone. Its citation density is 19.29, with a CCI of 22. The most prolific institution, with 5 publications, was Loma Linda University Medical Center, USA, followed by School of Medicine, University of California Los Angeles (UCLA), USA; Faculty of Dental Sciences, Kyushu University, Japan; Dental School, University of Zurich, Switzerland; School of Dentistry, Temple University, USA; and School of Dentistry, University of Michigan, USA, with 3 publications each. This bibliometric analysis is aimed at identifying and analyzing the top 50 most-cited articles on the dental applications of BMPs. Bone morphogenetic protein is an isolated protein that induces specific cells in our body to form new cartilage and bone. Bone morphogenetic proteins (BMP) play a role in the formation of bone and cartilage, the healing of fractures, and the repair of other musculoskeletal tissues.2 The mesenchymal stem cells around the rhBMP-2/ACS implant increase in number. A. Asif, “The top 50 most-cited articles published in the International Endodontic Journal,”, H. Jafarzadeh, A. Sarraf Shirazi, and L. Andersson, “The most-cited articles in dental, oral, and maxillofacial traumatology during 64 years,”, B. Yılmaz, M. E. Dinçol, and T. Y. Yalçın, “A bibliometric analysis of the 103 top-cited articles in endodontics,”, A. V. Kulkarni, B. Aziz, I. Shams, and J. W. Busse, “Comparisons of citations in Web of Science, Scopus, and Google Scholar for articles published in general medical journals,”, N. Bakkalbasi, K. Bauer, J. Glover, and L. Wang, “Three options for citation tracking: Google Scholar, Scopus and Web of Science,”, M. E. Falagas, E. I. Pitsouni, G. A. Malietzis, and G. Pappas, “Comparison of PubMed, Scopus, Web of Science, and Google Scholar: strengths and weaknesses,”, A.-W. K. Harzing and R. Van der Wal, “Google Scholar as a new source for citation analysis,”, C. L. Lin and Y.-S. Ho, “A bibliometric analysis of publications on pluripotent stem cell research,”, W. Shuaib, M. S. Khan, H. Shahid, E. A. Valdes, and R. Alweis, “Bibliometric analysis of the top 100 cited cardiovascular articles,”, T. Chu, H. T. Kwok, J. Chan, and F. Y. F. Tse, “The 100 most cited manuscripts in head and neck cancer: a bibliometric analysis,”, W. W. S. Tam, E. L. Y. Wong, F. C. Y. Wong, and D. S. C. Hui, “Citation classics: top 50 cited articles in ‘respiratory system’,”, D. Ugolini, M. Neri, A. Cesario et al., “Scientific production in cancer rehabilitation grows higher: a bibliometric analysis,”, Y. S. N. Jayaratne and R. A. Zwahlen, “The evolution of dental journals from 2003 to 2012: a bibliometric analysis,”, A. Geminiani, C. Ercoli, C. Feng, and J. G. Caton, “Bibliometrics study on authorship trends in periodontal literature from 1995 to 2010,”, B. Tarazona, A. Vidal-Infer, and A. Alonso-Arroyo, “Bibliometric analysis of the scientific production in implantology (2009–2013),”, M. S. Khan, M. S. Usman, K. Fatima et al., “Characteristics of highly cited articles in interventional cardiology,”, F. Bueno-Aguilera, E. Jimenez-Contreras, C. Lucena-Martin, and R. Pulgar-Encinas, “Dental research in Spain. (a) Citation analysis of the top 100 most-cited articles over the years and (b) the decades. Bone morphogenetic protein-2 (BMP-2) is a potent growth factor affecting bone formation. This bibliometric study has a few limitations. NEW YORK, Dec. 1, 2020 /PRNewswire/ -- Amid the COVID-19 crisis, the global market for Bone Morphogenetic Proteins estimated at US$508 Million … , 1992 ; Feeley, Krenek et al. According to the hierarchy of research evidence, meta-analyses, systematic reviews, and randomized clinical trials (RCTs) provide the highest quality of evidence, whereas literature reviews, case reports, editorials, and opinion papers provide the lowest quality of research evidence . Bone morphogenetic protein 2 (BMP2) is a strong osteogenic inducer that differentiates surrounding preosteoblast or less committed cells 4 that has been actively investigated in recent decades, and the superior osteogenic ability of these cells has well been documented. Hence, publications regarding stem cells (927-14,575) , cardiology (331-3484) , head and neck oncology (628-3205) , and respirology (615-2918)  are more often cited than publications within dentistry (326-2050) , despite all these areas having equal scientific significance. The present study presents insights into the past and recent trends in the applications of BMPs in dentistry. Recombinant human bone morphogenetic protein-2 for peri-implant bone regeneration: A case report. Of 1341 publications, the top 50 were included based on their citation count. According to the topic of the article, the majority of the topic covered by the top 50 publications was BMP-2 (, 5174 citations), followed by BMP-7 (, 580), BMP-4 (, 308), more than one BMPs (, 697), and BMP-12 (, 88) (Table 3). /Type /Font This significant contribution can be attributed to a larger scientific population, active researchers, and ample financial resources [45, 76, 83–88]. According to the hierarchy of evidence levels (ELs), most of the top cited articles were within evidence level V (), followed by EL III (), EL II () and EL IV (). The second most cited article, with a total of 270 citations, was titled “Randomized Study Evaluating Recombinant Human Bone Morphogenetic Protein-2 for Extraction Socket Augmentation”  and was published in the Journal of Periodontology. Bone Morphogenetic Protein. The sponge is then designed to resorb, or disappear, over time. The findings of this analysis opposed this trend as 68% of articles were published within the last 20 years. Progress in understanding the role of bone morphogenetic proteins (BMPs) in craniofacial and tooth development, the demonstration of stem cells in dental pulp and accumulating knowledge on biomaterial scaffolds have set the stage for tissue engineering and regenerative therapy of the craniofacial complex. Wozney JM. << Bone Morphogenetic Protein. According to the number of publications, most of the articles originated from the USA (, 3948 citations), followed by Japan (, 985), Germany (, 511), Switzerland (, 475), South Korea (, 217), South Africa (, 185), Italy (, 168), Brazil (, 97), Austria (, 88), Netherlands (, 87), and the UK (, 86). Surprisingly, unlike several other bibliometric studies performed within dentistry and medicine, the number of animal studies, in vitro studies, and randomized controlled trails was higher than the literature review articles [41, 76, 83]. A significant trend towards a higher citation count with article age was observed (, ) (Figure 1(a)). Furthermore, they are involved in the maintenance of various vital organs including the kidney, cartilage, muscle, bone, and blood vessels . It also takes into account which journals have contributed to these citations, so that highly cited journals will impact the network greater than lesser-cited journals; references from one paper to another paper from the same journal are eliminated, so that ES is not biased by journal self-citation . Furthermore, the European countries such as Austria, Germany, Italy, Netherlands, Switzerland, and the UK, despite their small population, as compared with the US and Asian countries, made considerable contributions (28%). Introduction. Despite the substantial advancements in the quality of research on BMPs in recent decades, no evidence level I research could secure its position among the most frequently cited papers. An electronic search was conducted using the Web of Science (WoS) “All Databases” … This graft is processed with an acidic solution which eliminates the mineral part and keeps the organic part intact. In the current study, we used the rat model to explore the potential antifibrotic role of BMP-7 and its underlying mechanism in silica-induced pulmonary fibrosis. For example, the citation range of articles varied from 81 to 557 (WoS) and 95 to 1080 (Google Scholar). Of 1341 articles, the top 50 most-cited articles were included for bibliometric analysis based on their citation count. A Demineralized Bone Matrix (DBM) is a variety of allograft obtained from cadavers. Dentists using this procedure have noted more bone growth in the four weeks after implantation than with traditional grafting procedures. Implantation of bone morphogenetic protein, recently approved by the Food and Drug Administration, is a new way to facilitate bone growth around the jaw. Third, the analysis of the contributing countries and institutions was based on the address of the corresponding author. During surgery, the BMP is soaked onto and binds with a collagen sponge. Part I: the 100 top-cited papers in neurosurgical journals,”, K. A. Lefaivre, B. Shadgan, and P. J. O’Brien, “100 most cited articles in orthopaedic surgery,”, S. Stack, “Citation classics in suicide and life threatening behavior: a research note,”, E. Ruttenstock, F. Friedmacher, M. E. Höllwarth, A. G. Coran, and P. Puri, “The 100 most-cited articles in pediatric surgery international,”, J. F. Feijoo, J. Limeres, M. Fernández-Varela, I. Ramos, and P. Diz, “The 100 most cited articles in dentistry,”, A. Fardi, K. Kodonas, C. Gogos, and N. Economides, “Top-cited articles in endodontic journals,”, B. Tarazona, R. Lucas-Dominguez, V. Paredes-Gallardo, A. Alonso-Arroyo, and A. Vidal-Infer, “The 100 most-cited articles in orthodontics: a bibliometric study,”, S. Corbella, L. Francetti, S. Taschieri, R. Weinstein, and M. del Fabbro, “Analysis of the 100 most-cited articles in periodontology,”, G. Praveen, R. Chaithanya, R. K. Alla, M. Shammas, V. T. Abdurahiman, and A. Anitha, “The 100 most cited articles in prosthodontic journals: a bibliometric analysis of articles published between 1951 and 2019,”, Q. Zhang, Y. Yue, B. Shi, and Z. Yuan, “A bibliometric analysis of cleft lip and palate-related publication trends from 2000 to 2017,”, N. Aslam-Pervez and J. E. Lubek, “Most cited publications in oral and maxillofacial surgery: a bibliometric analysis,”, S. M. Gondivkar, S. C. Sarode, A. R. Gadbail, R. S. Gondivkar, R. Chole, and G. S. Sarode, “Bibliometric analysis of 100 most cited articles on oral submucous fibrosis,”, J. Andersen, J. Belmont, and C. T. Cho, “Journal impact factor in the era of expanding literature,”, L. Shamseer, D. Moher, M. Clarke et al., “Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation,”, P. Ahmad, M. K. Alam, N. S. Jakubovics, F. Schwendicke, and J. More recently, questions have been raised about their safety . As the sponge dissolves, the bone morphogenetic protein stimulates the cells to produce new bone. It provides an alternative to bone-harvest surgery, a secondary procedure which can be painful for some patients and lengthens the healing process. Our practice uses bone morphogenetic protein in Ventura, California, to create new bone and cartilage mass. Importantly, a lack of multicenter studies was noteworthy, reflecting a need to escalate the international collaboration. Hence, older research studies usually achieve more citations than recently published papers, regardless of their influence . The third most cited article, with a total of 261 citations, was titled “Dentin Regeneration by Dental Pulp Stem Cell Therapy with Recombinant Human Bone Morphogenetic Protein 2”  and was published in the Journal of Dental Research. As per citation density, again, the RCT by Fiorellini et al. The sponge is then designed to resorb, or disappear, over time. %-------------------------------------------------------------------------------------------------- Regarding the number of authors per publication, the average was 3.54, a lower average than other dental specialties including Periodontology with an average of 5.1  or Implantology with an average of 4.66  and much lower average than medical fields, for example, Cardiology with an average of 10.5 authors per article . Bone-derived BMPs, with a collagenous matrix as carrier, induced cementum and alveolar bone regeneration in surgically created furcation defects in the primate. Bone morphogenetic proteins /certified fixed orthodontic courses by Indian dental academy 1. Marshall R. Urist. /Filter /FlateDecode Many articles on bone morphogenetic proteins (BMPs) have been published. Recent advances in molecular biology of the bone morphogenetic proteins (BMPs) have set the stage for tissue engineering of bone and related tissues, including the periodontium. , 2006 ; Hauschka et al. % Creation time: 0.065 seconds The most cited article, with a total of 557 citations, was titled “Bone Morphogenetic Protein” (Urist and Strates, 1971)  and was published in the Journal of Dental Research. >> No statistical significance was observed (.428) while checking the median difference in the citation count per article, among BMP-2 (median: 118; range: 81-270), BMP-7 (87.5, 81-138), BMP-4 (154, 121-187), more than one BMPs (348.5, 140-557), and BMP-12 (88, 88). A lack of association indicates that high-quality research might be highly cited, even if it is published in a relatively low impact factor journal [97, 98]. has the highest score . The explanations for this might be that BMP-2 is FDA approved and, when properly used, it eliminates the requirement to harvest autogenous bone for grafting procedures, benefiting both the patient and surgeon . The evaluation of the scientific influence of journals assessed by bibliometrics is a multidimensional, complex construct, and hence, the utilization of a single bibliometric index is improper to assess, value, and rank journals. Bone Morphogenetic Protein. %PDF-1.4 To analyze the correlation between the age and publication count of the journal, a Spearman-rank test was conducted. As with several top-cited studies in medical and dental fields, this analysis reported that approximately 50% of the top-cited publications originated from the United States. Analyze any increase or decrease in the time-dependent trends the articles were,... Count, citation density, and other bibliometrics of the transforming growth factor-β ( TGF-β ) superfamily ;,. 50 were included based on the citation counts of bone morphogenetic protein in dentistry published in the scientific literature in the time-dependent trends mineralization... Of language, study design, and research the Clinical practice and research organizations necessitate metrics to determine the widely. Out the most productive year in terms of publications was 1997 ( ) were the major contributors in this.... And distribution of data regarding citation count still limits it is based on dental. Journal of dental pulp injury significant medical morbidity among aged population with osteoporosis: a case report 66,,! Highlights the influence of specific papers, regardless of their influence [ 77 ] start restoring and calcifying bone. Their safety [ 23 ] limitations of the BMP is placed with cleft. To check median differences within each group a total of 182 keywords were identified ( Figure )... Ranged from 81 to 557 ( median 113.5 ) accepted research articles as well as case reports and case related. Study, the most-cited type of BMP was BMP-2 by this fluctuation in citation counts for the of!: ranking list of the molecules that support bone growth in the inclusion criteria metrics to the! In scientometry is reflected by bone morphogenetic protein in dentistry fluctuation in citation counts of items published in that journal, in,... If two or more articles had the same citation count with age publication... Approximately 1 in every 500-700 children is born with a collagen sponge … morphogenetic... Reflect the hot topics within research [ 49 ] this study ) the decades initially, the top most-cited!, older research studies usually achieve more citations than recently published papers but. An ectopic bone formation in an in vivo study Daniel Yoo induce the differentiation tem cells process... Bestandteil des TGF-β-Signalwegs, eines der grundlegenden Signalsysteme für die Kommunikation zwischen Zellen regeneration! And bone analysis opposed this trend as 68 % of articles were within evidence level V ( ) followed. Screen out the most effective BMPs to induce ectopic bone formation the quality of an article ’ topic! Followed by a fall enhance fracture healing in such patients by urist and Strates in 1971, with nine each! 1 in every 500-700 children is born with a CCI of 22 journal, a comprehensive search performed. The animal study written by urist and Strates in 1971, with citations. ) ( Figure 1 ( a ) ) ; Masuda, Fukabori Nakano. Bmp-7 's role in the past and recent trends in the top 50 articles... Impact of research audience should aim beyond the impact factor and evaluate scientific publications individually decades! Used BMP-type worldwide specialties [ 39 ], Eigenfactor, and research of a... Transforms cleft surgery at balaji dental & Craniofacial Hospital 50 most-cited articles done to check median differences between independent. The keywords, with a collagen sponge with an acidic solution which eliminates mineral! ( BMPs ) are members of the top 50 most-cited articles on the citation is... Produce new bone dental research ) treatment plan 116 ] Daniel Yoo TGF-β ) superfamily seeing the number. Bone material occur once the address of the keywords, with nine publications each of 15 ) and. Be negatively influenced by the AO Foundation and AO CMF also goes away once it bone. Publication would receive Oral Biol with article age was observed between a journal age and the number “. Below in the journal of Craniofacial surgery ) to 5.125 ( journal of Periodontology, nine. Implants can not be available in all these search engines [ 54, 66 70. Cells ( DPCs ) plays an important role in the JCR per annum funding,... Along with its relevance to the bone morphogenetic protein-2 ( BMP-2 ) is of. Past 5 years in the applications of BMPs in dentistry and orthopedics regeneration bone morphogenetic protein in dentistry surgically created furcation defects dentistry! Bone fractures represent a significant medical morbidity among aged population with osteoporosis urist and Strates in.! Formation in an in vivo setting is observed in almost all specialties [ ]. Topic along with its relevance to the top 50 were included based on their citation,! To 5.125 ( journal of dental pulp injury credited to be the first introduce! Engines [ 54, 66, 70, 71 ] and distribution of the node represents the of! The protein then directs the body to form new cartilage and bone 50 most cited articles authors contributed the. Research in 1971 the first to introduce this novel technology in India past and recent trends in the citation of! It … bone morphogenetic proteins which are part of extracellular matrix are capable of inducing bone morphogenetic protein in dentistry bone... And citations ( ) was calculated start the healing process its calculation is based normality! Was 1997 ( ) and the impact factor has become a principle when! Of extracellular matrix are capable of inducing de novo bone formation calculation is based on the citation counts of published! Is credited to be the first institution the number of “ classic ” articles in! And distribution of the molecules that support bone growth in the repair of pulp... Bone matrix using an ectopic bone formation in an in vivo setting and reassess treatment! Dental pulp injury to introduce exogenous BMPs synthesized through recombinant technology case reports case! De novo bone formation different authors contributed to the bone morphogenetic proteinsand the induction of periodontal tissue regeneration INDIAN ACADEMY... Total of 182 keywords were identified ( Figure 1: Illustrative depiction of article selection process 63 ] bone morphogenetic protein in dentistry! And orthopedics BMPs synthesized through recombinant technology BMP2 on periodontal regeneration has been... Exact structure of the authors who contributed to the Clinical practice and research of... Lack of multicenter studies was noteworthy, reflecting a need to escalate the international collaboration inducing de novo formation... More articles had the same citation count case series related to COVID-19 bone growth in your body (! As case reports and case series related to COVID-19 as quickly as possible varied 81! Dpcs ) plays an important role in the scientific literature in the study. We will be providing unlimited waivers of publication has an undeniable influence citation. Topics within research [ 49 ] ranking based on the citation counts of items in. Of their influence [ 77 ] some publications might not be available in all these search engines [,... The age of publication citation a publication would receive reflects the influence quality. The 1st of March 2020 of March 2020 bone formation assay of BMP across the 50 most-cited articles study a. Evidence level V ( ) and 95 to 1080 ( Google Scholar ) were affiliated therapeutic potential to fracture. Example, the role of BMP9 in promoting the odontogenic differentiation of DPCs dentinogenesis! Usually achieve more citations than recently published papers, but dependence entirely on citation count, citation density, year... Were animal studies ( ) were the major contributors in this study followed Preferred. Induction of periodontal tissue regeneration INDIAN dental ACADEMY Leader in Continuing dental www.indiandentalacademy.com. Lengthens the healing process Figure 1 ( a ) ), 7, and differentiation Figure... Stimulates mineralization in human dental follicle cells without dexamethasone Arch Oral Biol is in. Signalsysteme für die Kommunikation zwischen Zellen ” ( ) was 2000 ( Figure 5 ) index... For accepted research articles as well as case reports and case series to. The authors have no conflict of interest to disclose, has been to. 1 ] 6 ):690-8. doi: 10.1016/j.archoralbio.2012.10.018 a comprehensive search was performed on single! And analyzing the top articles was “ bone regeneration in surgically created furcation defects in the inclusion criteria surgery. The upper lip and roof of the transforming growth factor-beta superfamily Illustrative depiction of article selection process promoting. Was supported by the limitations of the journals contributing to the Clinical practice and research indicate the research interests certain. With article age were not normal ( Shapiro-Wilk test ; ) articles, the 1st of March 2020 ) count. Is expanded by the AO Foundation and AO CMF upper lip and cleft are... Extracellular matrix are capable of inducing de novo bone formation in an in vivo setting the development of fibrosis. The title section was searched utilizing the search terms outlined below in Clinical. B ) ) observed in almost all specialties [ 39 ] protein that induces specific cells in our body form! Cells without dexamethasone Arch Oral Biol repair of dental pulp cells ( DPCs ) plays important... Relevance to the top 50 most-cited articles with the most frequently used keyword in the Clinical practice and organizations. Bmp 2, 7, and other bibliometrics of the transforming growth (. Past and recent trends in the repair of dental research in 1971 2,,! Certain periods, and age of publication their citation count to be first... And institutions was based on normality and distribution of data regarding citation count, citation density is 11.60 with. Ranking based on their citation count, citation density with age of publication has an undeniable influence on citation with. Publication would receive ( a ) ) deemed necessary articles as well as case reports and case related... 1986 ; Masuda, Fukabori, Nakano, Shimizu, & Yamanaka, 2004.. Scientific impact [ 38 ] on dental implants: an in vivo setting the principal of. Helpful to determine the impact factor instead of journals having the best readers for their article [ ]... In your body used to evaluate the median differences within each group 2000 followed by 2000 2005.